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Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis.
Gebremariam, Teclegiorgis; Alkhazraji, Sondus; Gu, Yiyou; Singh, Shakti; Alqarihi, Abdullah; Shaw, Karen Joy; Ibrahim, Ashraf S.
Affiliation
  • Gebremariam T; The Lundquist Institute for Biomedical Innovations, Torrance, California, USA.
  • Alkhazraji S; The Lundquist Institute for Biomedical Innovations, Torrance, California, USA.
  • Gu Y; The Lundquist Institute for Biomedical Innovations, Torrance, California, USA.
  • Singh S; The Lundquist Institute for Biomedical Innovations, Torrance, California, USA.
  • Alqarihi A; The Lundquist Institute for Biomedical Innovations, Torrance, California, USA.
  • Shaw KJ; Amplyx Pharmaceuticals Inc., San Diego, California, USA kshaw@amplyx.com ibrahim@lundquist.org.
  • Ibrahim AS; The Lundquist Institute for Biomedical Innovations, Torrance, California, USA kshaw@amplyx.com ibrahim@lundquist.org.
Antimicrob Agents Chemother ; 64(1)2019 12 20.
Article in En | MEDLINE | ID: mdl-31685475
ABSTRACT
Galactomannan (GM) detection in biological samples has been shown to predict therapeutic response by azoles and polyenes. In a murine invasive pulmonary aspergillosis model, fosmanogepix or posaconazole treatment resulted in an ∼6- to 7-log reduction in conidial equivalents (CE)/g lung tissue after 96 h versus placebo. Changes in GM levels in BAL fluid and serum mirrored reductions in lung CE, with significant decreases seen after 96 h or 72 h for fosmanogepix or posaconazole, respectively (P < 0.02).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Invasive Pulmonary Aspergillosis / Mannans / Antifungal Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2019 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Invasive Pulmonary Aspergillosis / Mannans / Antifungal Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2019 Type: Article Affiliation country: United States