ADRs, adverse drug reactions; AE, adverse events; AIT, allergen immunotherapy; ANCOVA, analysis of covariance; ARC, adverse reaction complexes; Allergen immunotherapy; Allergoid; CIA-CPT, Culture ­ Independent Assessment of the Conjunctival Provocation Test; CPT, conjunctival provocation test; Cumulative dose; Curvilinear dose response; EAACI, European Academy of Allergy and Clinical Immunology; EMA, European Medicine Agency; FAS, Full Analysis Set; FEV, forced expiratory volume; FVC, forced vital capacity; Grass pollen; HEP, Histamine Equivalent Potency; LPS, lipopolysaccharide; MCP-Mod, Multiple Comparison Procedure and Modelling; MCT, microcrystalline tyrosine; MPL, Monophosphoryl Lipid A; MedDRA, Medical Dictionary for Regulatory Activities; PPS, Per Protocol Set; SAEs, serious adverse events; SAF, safety set; SAR, seasonal allergic rhinoconjunctivitis; SD, standard deviation; SU, standardized units; TEAEs, treatment-emergent adverse events; TLR, Toll-like receptor; TSS, Total Symptom Score; mFAS, Modified Full Analysis Set