High rates of antiretroviral coverage and virological suppression in HIV-1-infected children and adolescents.
Med Mal Infect
; 50(3): 269-273, 2020 May.
Article
in En
| MEDLINE
| ID: mdl-31722862
ABSTRACT
OBJECTIVES:
To assess the outcome of HIV-infected individuals attending one of the largest French pediatric HIV centers in 2016-2017 and to compare the rates of antiretroviral coverage and virological suppression with the UNAIDS targets. PATIENTS ANDMETHODS:
The clinical and immuno-virological status of 163 HIV-1-infected children and adolescents attending Necker Hospital in Paris, France, were investigated. Virological suppression was defined as an HIV-1 viral load<50 copies/mL for at least six months. All genotypic resistance tests performed since birth were analyzed.RESULTS:
Most patients were born in Sub-Saharan African countries (41.7%) or in France (38.0%). Their median age was 14 years [IQR 7.3-17.0]. Although 33.7% of individuals had a history of AIDS-defining clinical event(s), 86.5% of children/adolescents were free from HIV-related symptoms at their most recent evaluation. Antiretroviral coverage was high (98.2%; mainly including one integrase inhibitor [42.3%] or one protease inhibitor [23.9%]). At the last visit, most patients (82.8%) had normal CD4T lymphocytes counts (≥25%). Although 61.7% of antiretroviral-experienced children had resistance to≥1 drug class and 9.2% had triple-class resistance, 80.3% of patients receiving antiretrovirals for≥6 months (126/157) were virologically suppressed. International adoptees were more frequently virologically suppressed than other patients (96.0% versus 74.6%, P=0.02).CONCLUSIONS:
Antiretroviral coverage exceeded the second UNAIDS 90 target aimed at ending the AIDS epidemic. The rate of virological suppression, one of the highest reported in children in high-income countries, is approaching the third UNAIDS 90 target and the rate observed in French HIV-infected adults on antiretrovirals.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viremia
/
HIV Infections
/
HIV-1
/
Anti-HIV Agents
/
Viral Load
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
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Male
/
Newborn
Country/Region as subject:
Africa
/
Asia
/
Europa
Language:
En
Journal:
Med Mal Infect
Year:
2020
Type:
Article
Affiliation country:
France