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Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.
Campbell, Patricia Therese; Tong, Steven Y C; Geard, Nicholas; Davies, Mark R; Worthing, Kate A; Lacey, Jake A; Smeesters, Pierre R; Batzloff, Michael R; Kado, Joseph; Jenney, Adam W J; Mcvernon, Jodie; Steer, Andrew C.
Affiliation
  • Campbell PT; Victorian Infectious Diseases Reference Laboratory Epidemiology Unit, The Peter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.
  • Tong SYC; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia.
  • Geard N; Victorian Infectious Diseases Reference Laboratory Epidemiology Unit, The Royal Melbourne Hospital, Melbourne, Australia.
  • Davies MR; Doherty Department at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
  • Worthing KA; Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
  • Lacey JA; Victorian Infectious Diseases Reference Laboratory Epidemiology Unit, The Peter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.
  • Smeesters PR; School of Computing and Information Systems, Melbourne School of Engineering, The University of Melbourne, Australia.
  • Batzloff MR; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Kado J; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Jenney AWJ; Doherty Department at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
  • Mcvernon J; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia.
  • Steer AC; Molecular Bacteriology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.
J Infect Dis ; 221(9): 1429-1437, 2020 04 07.
Article in En | MEDLINE | ID: mdl-31748786
ABSTRACT
Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relationship between infection, colonization, and immunity is still not completely understood. The M protein, encoded by the emm gene, is a major virulence factor and vaccine candidate and forms the basis of a number of classification systems. Longitudinal patterns of emm types collected from 457 Fijian schoolchildren over a 10-month period were analyzed. No evidence of tissue tropism was observed, and there was no apparent selective pressure or constraint of emm types. Patterns of emm type acquisition suggest limited, if any, modification of future infection based on infection history. Where impetigo is the dominant mode of transmission, circulating emm types either may not be constrained by ecological niches or population immunity to the M protein, or they may require several infections over a longer period of time to induce such immunity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptococcal Infections / Streptococcus pyogenes / Bacterial Outer Membrane Proteins / Carrier Proteins / Skin Diseases, Bacterial / Antigens, Bacterial Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: J Infect Dis Year: 2020 Type: Article Affiliation country: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptococcal Infections / Streptococcus pyogenes / Bacterial Outer Membrane Proteins / Carrier Proteins / Skin Diseases, Bacterial / Antigens, Bacterial Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: J Infect Dis Year: 2020 Type: Article Affiliation country: Australia