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Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation.
Shi, Haibin; Tice, Colin M; Emert-Sedlak, Lori; Chen, Li; Li, Wing Fai; Carlsen, Marianne; Wrobel, Jay E; Reitz, Allen B; Smithgall, Thomas E.
Affiliation
  • Shi H; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.
  • Tice CM; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
  • Emert-Sedlak L; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.
  • Chen L; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.
  • Li WF; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.
  • Carlsen M; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
  • Wrobel JE; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
  • Reitz AB; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
  • Smithgall TE; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.
ACS Infect Dis ; 6(2): 302-312, 2020 02 14.
Article in En | MEDLINE | ID: mdl-31775511
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Virus Replication / Histocompatibility Antigens Class I / Anti-Retroviral Agents / Nef Gene Products, Human Immunodeficiency Virus Type of study: Prognostic_studies Limits: Humans Language: En Journal: ACS Infect Dis Year: 2020 Type: Article Affiliation country: United States
Fulltext
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Virus Replication / Histocompatibility Antigens Class I / Anti-Retroviral Agents / Nef Gene Products, Human Immunodeficiency Virus Type of study: Prognostic_studies Limits: Humans Language: En Journal: ACS Infect Dis Year: 2020 Type: Article Affiliation country: United States