Detection of autoantibodies against GABAARα1 in patients with schizophrenia.
Schizophr Res
; 216: 543-546, 2020 Feb.
Article
in En
| MEDLINE
| ID: mdl-31806526
ABSTRACT
Recent studies have identified autoantibodies against synaptic molecules in patients with encephalitis. Autoantibodies against the N-Methyl-d-Aspartate receptor have been reported in patients with schizophrenia; however, autoantibodies against other molecules are yet to be identified. This study used a cell-based assay to examine serum samples from individuals with schizophrenia and healthy controls. The results showed that 5 (8.6%) of 57 patients with schizophrenia harbor autoantibodies against the α1 subunit of the γ-aminobutyric acid A receptor (GABAARα1), which are currently not know to be linked to the pathology of this disease. Some patients showed markedly high antibody titers (i.e., 110,000-100,000). None of the heathy control subjects were positive for GABAARα1 antibodies. Therefore, these autoantibodies may form the basis of GABA-mediated pathology in a subgroup of patients with schizophrenia.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Encephalitis
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Schizophr Res
Journal subject:
PSIQUIATRIA
Year:
2020
Type:
Article