Cell Culture Studies of the Efficacy and Barrier to Resistance of Sofosbuvir-Velpatasvir and Glecaprevir-Pibrentasvir against Hepatitis C Virus Genotypes 2a, 2b, and 2c.

Ramirez, Santseharay; Fernandez-Antunez, Carlota; Mikkelsen, Lotte S; Pedersen, Jannie; Li, Yi-Ping; Bukh, Jens

Ramirez, Santseharay; Fernandez-Antunez, Carlota; Mikkelsen, Lotte S; Pedersen, Jannie; Li, Yi-Ping; Bukh, Jens.

Affiliation

Ramirez S; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark santseharayra@sund.ku.dk jbukh@sund.ku.dk.
Fernandez-Antunez C; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mikkelsen LS; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark.
Pedersen J; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Li YP; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark.
Bukh J; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Antimicrob Agents Chemother ; 64(3)2020 02 21.

Article in En | MEDLINE | ID: mdl-31818814

Subject(s)

Antiviral Agents/pharmacology; Benzimidazoles/pharmacology; Carbamates/pharmacology; Drug Resistance, Viral/genetics; Hepacivirus/drug effects; Heterocyclic Compounds, 4 or More Rings/pharmacology; Pyrrolidines/pharmacology; Quinoxalines/pharmacology; Sofosbuvir/pharmacology; Sulfonamides/pharmacology; Viral Nonstructural Proteins/genetics; Cell Line, Tumor; Culture Media/chemistry; Drug Combinations; Drug Therapy, Combination; Gene Expression; Genotype; Hepacivirus/enzymology; Hepacivirus/genetics; Hepacivirus/isolation & purification; Hepatitis C, Chronic/drug therapy; Hepatitis C, Chronic/pathology; Hepatitis C, Chronic/virology; Hepatocytes/drug effects; Hepatocytes/virology; Humans; Microbial Sensitivity Tests; Mutation; RNA, Viral/genetics; RNA, Viral/metabolism; Viral Nonstructural Proteins/metabolism

Key words

DAA; HCVcc; NS5A inhibitor; RAS; genotype 2; nucleotide analog; protease inhibitor; treatment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyrrolidines / Quinoxalines / Sulfonamides / Benzimidazoles / Carbamates / Viral Nonstructural Proteins / Hepacivirus / Drug Resistance, Viral / Sofosbuvir Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2020 Type: Article

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