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High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer.
Kawashima, Masahiro; Tokiwa, Mariko; Nishimura, Tomomi; Kawata, Yukiko; Sugimoto, Masahiro; Kataoka, Tatsuki R; Sakurai, Takaki; Iwaisako, Keiko; Suzuki, Eiji; Hagiwara, Masatoshi; Harris, Adrian L; Toi, Masakazu.
Affiliation
  • Kawashima M; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606 8507, Japan. masa0123@kuhp.kyoto-u.ac.jp.
  • Tokiwa M; Molecular Oncology Laboratories, Wheaterall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK. masa0123@kuhp.kyoto-u.ac.jp.
  • Nishimura T; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606 8507, Japan.
  • Kawata Y; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606 8507, Japan.
  • Sugimoto M; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606 8507, Japan.
  • Kataoka TR; Health Promotion and Preemptive Medicine, Research and Development Center for Minimally Invasive Therapies, Tokyo Medical University, Sinjuku-ku, Tokyo, 160-8402, Japan.
  • Sakurai T; Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Iwaisako K; Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Suzuki E; Department of Target Therapy Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Hagiwara M; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606 8507, Japan.
  • Harris AL; Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  • Toi M; Medical Research Support Center, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Br J Cancer ; 122(2): 245-257, 2020 01.
Article in En | MEDLINE | ID: mdl-31819188
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositols / Breast Neoplasms / Fatty Acids / Transcriptome Limits: Aged / Animals / Female / Humans / Middle aged Language: En Journal: Br J Cancer Year: 2020 Type: Article Affiliation country: Japan
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositols / Breast Neoplasms / Fatty Acids / Transcriptome Limits: Aged / Animals / Female / Humans / Middle aged Language: En Journal: Br J Cancer Year: 2020 Type: Article Affiliation country: Japan