Methods for dynamic synchrotron X-ray respiratory imaging in live animals.
J Synchrotron Radiat
; 27(Pt 1): 164-175, 2020 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-31868749
ABSTRACT
Small-animal physiology studies are typically complicated, but the level of complexity is greatly increased when performing live-animal X-ray imaging studies at synchrotron and compact light sources. This group has extensive experience in these types of studies at the SPring-8 and Australian synchrotrons, as well as the Munich Compact Light Source. These experimental settings produce unique challenges. Experiments are always performed in an isolated radiation enclosure not specifically designed for live-animal imaging. This requires equipment adapted to physiological monitoring and test-substance delivery, as well as shuttering to reduce the radiation dose. Experiment designs must also take into account the fixed location, size and orientation of the X-ray beam. This article describes the techniques developed to overcome the challenges involved in respiratory X-ray imaging of live animals at synchrotrons, now enabling increasingly sophisticated imaging protocols.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory System
/
Radiography
/
Respiratory Mechanics
/
Synchrotrons
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
J Synchrotron Radiat
Journal subject:
RADIOLOGIA
Year:
2020
Type:
Article
Affiliation country:
Australia