Statin-Induced Chronic Cholesterol Depletion Switches GPCR Endocytosis and Trafficking: Insights from the Serotonin<sub>1A</sub> Receptor.

Kumar, G Aditya; Chattopadhyay, Amitabha

Statin-Induced Chronic Cholesterol Depletion Switches GPCR Endocytosis and Trafficking: Insights from the Serotonin_1A Receptor.

Kumar, G Aditya; Chattopadhyay, Amitabha.

Affiliation

Kumar GA; CSIR-Centre for Cellular and Molecular Biology , Uppal Road , Hyderabad 500 007 , India.
Chattopadhyay A; CSIR-Centre for Cellular and Molecular Biology , Uppal Road , Hyderabad 500 007 , India.

ACS Chem Neurosci ; 11(3): 453-465, 2020 02 05.

Article in En | MEDLINE | ID: mdl-31880914

Subject(s)

Endocytosis/drug effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Receptor, Serotonin, 5-HT1A/drug effects; Receptors, G-Protein-Coupled/drug effects; Cell Membrane/drug effects; Cell Membrane/metabolism; Cell Movement/drug effects; Endocytosis/physiology; Humans; Membrane Lipids/metabolism; Protein Transport/drug effects; Protein Transport/physiology; Receptor, Serotonin, 5-HT1A/metabolism; Receptors, G-Protein-Coupled/metabolism

Key words

G protein-coupled receptors; cholesterol; endocytosis; intracellular trafficking; serotonin1A receptor; statin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / Receptors, G-Protein-Coupled / Receptor, Serotonin, 5-HT1A / Endocytosis Limits: Humans Language: En Journal: ACS Chem Neurosci Year: 2020 Type: Article Affiliation country: India

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