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Stressed-Out T Cells Fragment the Mind.
Bordt, Evan A; Bilbo, Staci D.
Affiliation
  • Bordt EA; Pediatrics and Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Bilbo SD; Pediatrics and Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Psychology and Neuroscience, and Department of Neurobiology, Duke University, Durham, NC 27708, USA. Electronic address: staci.bilbo@duke.edu.
Trends Immunol ; 41(2): 94-97, 2020 02.
Article in En | MEDLINE | ID: mdl-31917111
The immune system is increasingly recognized to play an integral role in regulating stress responses. In a recent article in Cell, Fan et al. demonstrate a novel mechanism through which stress drives mitochondrial fragmentation-induced xanthine accumulation in mouse CD4+ T cells, subsequently acting on oligodendrocytes to induce anxiety-like behaviors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP Citrate (pro-S)-Lyase / Histones Limits: Animals / Humans Language: En Journal: Trends Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP Citrate (pro-S)-Lyase / Histones Limits: Animals / Humans Language: En Journal: Trends Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: United States