The investigation of synergistic activity of protamine with conventional antimicrobial agents against oral bacteria.
Biochem Biophys Res Commun
; 523(3): 561-566, 2020 03 12.
Article
in En
| MEDLINE
| ID: mdl-31932035
ABSTRACT
In this study, we applied protamine, which is an antimicrobial peptide, to oral healthcare in combination with conventional antimicrobial agents. First, we explored the antimicrobial activity of protamine, with or without other antimicrobial agents, against Streptococcus mutans (S. mutans). Co-treatment with protamine and 3-methyl-4-isopropylphenol (IPMP) decreased the viability of S. mutans synergistically within 10 min. Interestingly, sodium fluoride (NaF) did not exhibit synergistic activity with protamine. Next, S. mutans and Streptococcus gordonii (S. gordonii) were co-treated with protamine and IPMP for 5 min to simulate tooth brushing. As a result, this co-treatment killed S. mutans faster than S. gordonii. Therefore, co-treatment with protamine and IPMP could be incorporated into oral healthcare products to prevent dental caries.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptococcus mutans
/
Protamines
/
Streptococcus gordonii
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2020
Type:
Article
Affiliation country:
Japan