MiR-143 Inhibits Osteoclastogenesis by Targeting RANK and NF-&#954;B and MAPK Signaling Pathways.

He, Xianfeng; Zhu, Limei; An, Lin; Zhang, Jingwei

MiR-143 Inhibits Osteoclastogenesis by Targeting RANK and NF-κB and MAPK Signaling Pathways.

He, Xianfeng; Zhu, Limei; An, Lin; Zhang, Jingwei.

Affiliation

He X; Department of Orthopedics, Ningbo NO.6 Hospital, Ningbo, 315040, China.
Zhu L; Department of Orthopedics, Ningbo NO.6 Hospital, Ningbo, 315040, China.
An L; Department of Orthopedics, Ningbo NO.6 Hospital, Ningbo, 315040, China.
Zhang J; Department of Orthopedics, Ningbo NO.6 Hospital, Ningbo, 315040, China.

Curr Mol Pharmacol ; 13(3): 224-232, 2020.

Article in En | MEDLINE | ID: mdl-31951177

Subject(s)

MicroRNAs/genetics; Osteoclasts/drug effects; Receptor Activator of Nuclear Factor-kappa B/antagonists & inhibitors; Signal Transduction/drug effects; Animals; Gene Expression Regulation/drug effects; MAP Kinase Signaling System/drug effects; Mice; NF-KappaB Inhibitor alpha/biosynthesis; NF-KappaB Inhibitor alpha/genetics; NFATC Transcription Factors/biosynthesis; NFATC Transcription Factors/genetics; Osteoclasts/metabolism; RANK Ligand/genetics; RAW 264.7 Cells; RNA, Messenger/biosynthesis; Receptor Activator of Nuclear Factor-kappa B/biosynthesis; Receptor Activator of Nuclear Factor-kappa B/genetics; Recombinant Proteins/metabolism; TNF Receptor-Associated Factor 6/biosynthesis; TNF Receptor-Associated Factor 6/genetics; Transcription Factor RelA/biosynthesis; Transcription Factor RelA/genetics

Key words

MAPK; MiR-143; NF-κB; RANK; RANK/RANKL; TRAF6; osteoclastogenesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Signal Transduction / MicroRNAs / Receptor Activator of Nuclear Factor-kappa B Limits: Animals Language: En Journal: Curr Mol Pharmacol Journal subject: FARMACOLOGIA Year: 2020 Type: Article Affiliation country: China

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