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Fe-catalyzed Decarbonylative Alkylative Spirocyclization of N-Arylcinnamamides: Access to Alkylated 1-Azaspirocyclohexadienones.
Peng, Xiang; Liu, Ren-Xiang; Xiao, Xiang-Yan; Yang, Luo.
Affiliation
  • Xiao XY; Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
  • Yang L; Key Laboratory for Environmentally Friendly Chemistry and Application of the Ministry of Education, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
Molecules ; 25(3)2020 Jan 21.
Article in En | MEDLINE | ID: mdl-31972970
ABSTRACT
For the convenient introduction of simple linear/branched alkyl groups into biologically important azaspirocyclohexadienones, a practical Fe-catalyzed decarbonylative cascade spiro-cyclization of N-aryl cinnamamides with aliphatic aldehydes to provide alkylated 1-azaspiro-cyclohexadienones was developed. Aliphatic aldehydes were oxidative decarbonylated into primary, secondary and tertiary alkyl radicals conveniently and allows for the subsequent cascade construction of dual C(sp3)-C(sp3) and C=O bonds via radical addition, spirocyclization and oxidation sequence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Aza Compounds / Cinnamates / Alkylating Agents / Cyclohexenes / Iron Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2020 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Aza Compounds / Cinnamates / Alkylating Agents / Cyclohexenes / Iron Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2020 Type: Article