Fe-catalyzed Decarbonylative Alkylative Spirocyclization of N-Arylcinnamamides: Access to Alkylated 1-Azaspirocyclohexadienones.
Molecules
; 25(3)2020 Jan 21.
Article
in En
| MEDLINE
| ID: mdl-31972970
ABSTRACT
For the convenient introduction of simple linear/branched alkyl groups into biologically important azaspirocyclohexadienones, a practical Fe-catalyzed decarbonylative cascade spiro-cyclization of N-aryl cinnamamides with aliphatic aldehydes to provide alkylated 1-azaspiro-cyclohexadienones was developed. Aliphatic aldehydes were oxidative decarbonylated into primary, secondary and tertiary alkyl radicals conveniently and allows for the subsequent cascade construction of dual C(sp3)-C(sp3) and C=O bonds via radical addition, spirocyclization and oxidation sequence.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spiro Compounds
/
Aza Compounds
/
Cinnamates
/
Alkylating Agents
/
Cyclohexenes
/
Iron
Language:
En
Journal:
Molecules
Journal subject:
BIOLOGIA
Year:
2020
Type:
Article