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Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips.
Herland, Anna; Maoz, Ben M; Das, Debarun; Somayaji, Mahadevabharath R; Prantil-Baun, Rachelle; Novak, Richard; Cronce, Michael; Huffstater, Tessa; Jeanty, Sauveur S F; Ingram, Miles; Chalkiadaki, Angeliki; Benson Chou, David; Marquez, Susan; Delahanty, Aaron; Jalili-Firoozinezhad, Sasan; Milton, Yuka; Sontheimer-Phelps, Alexandra; Swenor, Ben; Levy, Oren; Parker, Kevin K; Przekwas, Andrzej; Ingber, Donald E.
Affiliation
  • Herland A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Maoz BM; Division of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.
  • Das D; AIMES, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
  • Somayaji MR; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Prantil-Baun R; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
  • Novak R; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.
  • Cronce M; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Huffstater T; CFD Research Corporation, Huntsville, AL, USA.
  • Jeanty SSF; CFD Research Corporation, Huntsville, AL, USA.
  • Ingram M; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Chalkiadaki A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Benson Chou D; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Marquez S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Delahanty A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Jalili-Firoozinezhad S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Milton Y; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Sontheimer-Phelps A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Swenor B; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Levy O; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Parker KK; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
  • Przekwas A; Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Portugal Graduate Program, Universidade de Lisboa, Lisbon, Portugal.
  • Ingber DE; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Nat Biomed Eng ; 4(4): 421-436, 2020 04.
Article in En | MEDLINE | ID: mdl-31988459
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Pharmaceutical Preparations / Microfluidics / Lab-On-A-Chip Devices Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Nat Biomed Eng Year: 2020 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Pharmaceutical Preparations / Microfluidics / Lab-On-A-Chip Devices Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Nat Biomed Eng Year: 2020 Type: Article Affiliation country: United States