The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge.

Crespo-Castrillo, Andrea; Garcia-Segura, Luis-Miguel; Arevalo, Maria-Angeles

Crespo-Castrillo, Andrea; Garcia-Segura, Luis-Miguel; Arevalo, Maria-Angeles.

Affiliation

Crespo-Castrillo A; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Garcia-Segura LM; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Arevalo MA; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludables (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.

J Neuroinflammation ; 17(1): 37, 2020 Jan 28.

Article in En | MEDLINE | ID: mdl-31992325

Subject(s)

Astrocytes/drug effects; Inflammation/pathology; Norpregnenes/pharmacology; Phagocytosis/drug effects; Selective Estrogen Receptor Modulators/pharmacology; Androgen Receptor Antagonists/pharmacology; Animals; Estradiol/biosynthesis; Estrogen Antagonists/pharmacology; Female; Glial Fibrillary Acidic Protein/metabolism; Inflammation/chemically induced; Lipopolysaccharides; Male; Microglia/drug effects; Rats; Rats, Wistar

Key words

Androgen receptor; Astrocytes; Cellular debris; Estrogen receptor; LPS; Phagocytosis; Sex differences; Tibolone

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Astrocytes / Selective Estrogen Receptor Modulators / Inflammation / Norpregnenes Limits: Animals Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2020 Type: Article Affiliation country: Spain

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