Improved Host Cell Protein Analysis in Monoclonal Antibody Products through Molecular Weight Cutoff Enrichment.

Chen, I-Hsuan; Xiao, Hui; Daly, Thomas; Li, Ning

Chen, I-Hsuan; Xiao, Hui; Daly, Thomas; Li, Ning.

Affiliation

Chen IH; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6706, United States.
Xiao H; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6706, United States.
Daly T; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6706, United States.
Li N; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6706, United States.

Anal Chem ; 92(5): 3751-3757, 2020 03 03.

Article in En | MEDLINE | ID: mdl-31999105

Subject(s)

Antibodies, Monoclonal/metabolism; Peptides/isolation & purification; Recombinant Proteins/metabolism; Ultrafiltration; Animals; Antibodies, Monoclonal/genetics; CHO Cells; Chemokines, CXC/analysis; Chemokines, CXC/metabolism; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Limit of Detection; Molecular Weight; Peptides/analysis; Prealbumin/analysis; Prealbumin/metabolism; Recombinant Proteins/isolation & purification; Sarcosine/analogs & derivatives; Sarcosine/chemistry; Tandem Mass Spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Recombinant Proteins / Ultrafiltration / Antibodies, Monoclonal Type of study: Qualitative_research Limits: Animals Language: En Journal: Anal Chem Year: 2020 Type: Article Affiliation country: United States

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