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"Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolution.
Rege, Nischay K; Liu, Ming; Dhayalan, Balamurugan; Chen, Yen-Shan; Smith, Nicholas A; Rahimi, Leili; Sun, Jinhong; Guo, Huan; Yang, Yanwu; Haataja, Leena; Phillips, Nelson F B; Whittaker, Jonathan; Smith, Brian J; Arvan, Peter; Ismail-Beigi, Faramarz; Weiss, Michael A.
Affiliation
  • Rege NK; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106.
  • Liu M; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48105, Australia; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, Heping District, 300052 China.
  • Dhayalan B; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
  • Chen YS; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
  • Smith NA; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
  • Rahimi L; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106; Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
  • Sun J; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48105, Australia.
  • Guo H; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48105, Australia.
  • Yang Y; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
  • Haataja L; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48105, Australia.
  • Phillips NFB; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106.
  • Whittaker J; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106.
  • Smith BJ; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
  • Arvan P; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48105, Australia.
  • Ismail-Beigi F; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106; Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
  • Weiss MA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202. Electronic address: weissma@iu.edu.
J Biol Chem ; 295(10): 3080-3098, 2020 03 06.
Article in En | MEDLINE | ID: mdl-32005662
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Evolution, Molecular / Insulin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2020 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Evolution, Molecular / Insulin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2020 Type: Article