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Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate.
Vlahov, Iontcho R; Qi, Longwu; Santhapuram, Hari Krishna R; Felten, Albert; Parham, Garth L; Zou, Ning; Wang, Kevin; You, Fei; Vaughn, Jeremy F; Hahn, Spencer J; Klein, Hanna F; Kleindl, Paul J; Reddy, Joe; Reno, Dan; Nicoson, Jeff; Leamon, Christopher P.
Affiliation
  • Vlahov IR; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA. Electronic address: iontcho.vlahov@adacap.com.
  • Qi L; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Santhapuram HKR; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Felten A; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Parham GL; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Zou N; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Wang K; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • You F; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Vaughn JF; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Hahn SJ; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Klein HF; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Kleindl PJ; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Reddy J; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Reno D; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Nicoson J; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
  • Leamon CP; Endocyte Inc., 3000 Kent Ave., W. Lafayette, IN 47906, USA.
Bioorg Med Chem Lett ; 30(7): 126987, 2020 04 01.
Article in En | MEDLINE | ID: mdl-32029324
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Benzodiazepines / Prodrugs / Folate Receptors, GPI-Anchored / Antibiotics, Antineoplastic / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Benzodiazepines / Prodrugs / Folate Receptors, GPI-Anchored / Antibiotics, Antineoplastic / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article