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Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy.
Khan, Anzer; Paro, Simona; McGurk, Leeanne; Sambrani, Nagraj; Hogg, Marion C; Brindle, James; Pennetta, Giuseppa; Keegan, Liam P; O'Connell, Mary A.
Affiliation
  • Khan A; CEITEC Masaryk University, Kamenice 735/5, A35, CZ 62 500, Brno, Czech Republic.
  • Paro S; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
  • McGurk L; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Sambrani N; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Hogg MC; CEITEC Masaryk University, Kamenice 735/5, A35, CZ 62 500, Brno, Czech Republic.
  • Brindle J; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Pennetta G; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
  • Keegan LP; Centre for Integrative Physiology, Euan MacDonald Centre for Motor Neurone Disease Research, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh, EH8 9XD, UK.
  • O'Connell MA; CEITEC Masaryk University, Kamenice 735/5, A35, CZ 62 500, Brno, Czech Republic. Liam.Keegan@ceitec.muni.cz.
BMC Biol ; 18(1): 15, 2020 02 14.
Article in En | MEDLINE | ID: mdl-32059717
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Adenosine Deaminase / Synaptic Transmission / Drosophila Proteins / Drosophila melanogaster Limits: Animals Language: En Journal: BMC Biol Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: Czech Republic
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Adenosine Deaminase / Synaptic Transmission / Drosophila Proteins / Drosophila melanogaster Limits: Animals Language: En Journal: BMC Biol Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: Czech Republic