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GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone.
Suh, Joonho; Kim, Na-Kyung; Lee, Seung-Hoon; Eom, Je-Hyun; Lee, Youngkyun; Park, Joo-Cheol; Woo, Kyung Mi; Baek, Jeong-Hwa; Kim, Jung-Eun; Ryoo, Hyun-Mo; Lee, Se-Jin; Lee, Yun-Sil.
Affiliation
  • Suh J; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
  • Kim NK; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
  • Lee SH; Department of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
  • Eom JH; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
  • Lee Y; Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu 41566, Republic of Korea.
  • Park JC; Department of Oral Histology-Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
  • Woo KM; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
  • Baek JH; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
  • Kim JE; Department of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.
  • Ryoo HM; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
  • Lee SJ; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.
  • Lee YS; Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT 06030.
Proc Natl Acad Sci U S A ; 117(9): 4910-4920, 2020 03 03.
Article in En | MEDLINE | ID: mdl-32071240
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteogenesis / Bone and Bones / Bone Morphogenetic Proteins / Muscle Development / Growth Differentiation Factors / Myostatin Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteogenesis / Bone and Bones / Bone Morphogenetic Proteins / Muscle Development / Growth Differentiation Factors / Myostatin Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article