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Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes.
Saenwongsa, Wipawee; Nithichanon, Arnone; Chittaganpitch, Malinee; Buayai, Kampaew; Kewcharoenwong, Chidchamai; Thumrongwilainet, Boonyarat; Butta, Patcharavadee; Palaga, Tanapat; Takahashi, Yoshimasa; Ato, Manabu; Lertmemongkolchai, Ganjana.
Affiliation
  • Saenwongsa W; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
  • Nithichanon A; Disease Prevention and Control Region 10th, Ubonratchathani, Ministry of Public Health, Mueang Nonthaburi, Thailand.
  • Chittaganpitch M; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
  • Buayai K; National Influenza Centre, Department of Medical Science, Ministry of Public Health, Mueang Nonthaburi, Thailand.
  • Kewcharoenwong C; National Influenza Centre, Department of Medical Science, Ministry of Public Health, Mueang Nonthaburi, Thailand.
  • Thumrongwilainet B; Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
  • Butta P; Yanglum Health Promotion Hospital, Ubonratchathani, Thailand.
  • Palaga T; Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
  • Takahashi Y; Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
  • Ato M; National Institute of Infectious Diseases, Tokyo, Japan.
  • Lertmemongkolchai G; National Institute of Infectious Diseases, Tokyo, Japan.
Sci Rep ; 10(1): 3229, 2020 02 24.
Article in En | MEDLINE | ID: mdl-32094377
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seasons / Signal Transduction / Vaccination / Interferon-alpha / Diabetes Mellitus, Type 2 / Mechanistic Target of Rapamycin Complex 1 / Metformin / Antibody Formation Type of study: Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: Thailand
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seasons / Signal Transduction / Vaccination / Interferon-alpha / Diabetes Mellitus, Type 2 / Mechanistic Target of Rapamycin Complex 1 / Metformin / Antibody Formation Type of study: Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: Thailand