Heterotrimeric G<sub>q</sub> proteins as therapeutic targets?

Kostenis, Evi; Pfeil, Eva Marie; Annala, Suvi

Heterotrimeric G_q proteins as therapeutic targets?

Kostenis, Evi; Pfeil, Eva Marie; Annala, Suvi.

Affiliation

Kostenis E; Section of Molecular, Cellular and Pharmacobiology, Institute of Pharmaceutical Biology, Nussallee 6, 53115 Bonn, Germany. Electronic address: kostenis@uni-bonn.de.
Pfeil EM; Section of Molecular, Cellular and Pharmacobiology, Institute of Pharmaceutical Biology, Nussallee 6, 53115 Bonn, Germany.
Annala S; Section of Molecular, Cellular and Pharmacobiology, Institute of Pharmaceutical Biology, Nussallee 6, 53115 Bonn, Germany.

J Biol Chem ; 295(16): 5206-5215, 2020 04 17.

Article in En | MEDLINE | ID: mdl-32122969

Subject(s)

Antineoplastic Agents/pharmacology; Depsipeptides/pharmacology; GTP-Binding Protein alpha Subunits, Gq-G11/antagonists & inhibitors; Oncogene Proteins/antagonists & inhibitors; Animals; Antineoplastic Agents/chemistry; Depsipeptides/chemistry; Drug Discovery/methods; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism; Humans; Oncogene Proteins/metabolism; Signal Transduction

Key words

FR900359; G protein; G protein-coupled receptor (GPCR); Gq; Gq inhibitor; YM254890; cancer; cancer biology; cancer therapy; cell signaling; heterotrimeric G protein; oncogene; oncoprotein; signal transduction; signaling; uveal melanoma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins / GTP-Binding Protein alpha Subunits, Gq-G11 / Depsipeptides / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2020 Type: Article

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