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Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing.
Hanzawa, Nozomi; Hashimoto, Koshi; Yuan, Xunmei; Kawahori, Kenichi; Tsujimoto, Kazutaka; Hamaguchi, Miho; Tanaka, Toshiya; Nagaoka, Yuya; Nishina, Hiroshi; Morita, Sumiyo; Hatada, Izuho; Yamada, Tetsuya; Ogawa, Yoshihiro.
Affiliation
  • Hanzawa N; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Hashimoto K; Department of Preemptive Medicine and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. k-hashi@dokkyomed.ac.jp.
  • Yuan X; Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan. k-hashi@dokkyomed.ac.jp.
  • Kawahori K; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Tsujimoto K; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Hamaguchi M; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Tanaka T; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Nagaoka Y; Laboratories for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, 153-8904, Japan.
  • Nishina H; Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Morita S; Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Hatada I; Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8512, Japan.
  • Yamada T; Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8512, Japan.
  • Ogawa Y; Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Sci Rep ; 10(1): 5181, 2020 03 20.
Article in En | MEDLINE | ID: mdl-32198422
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibroblast Growth Factors / DNA Demethylation Limits: Animals Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibroblast Growth Factors / DNA Demethylation Limits: Animals Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: Japan