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Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging.
Godard, Amélie; Kalot, Ghadir; Pliquett, Jacques; Busser, Benoit; Le Guével, Xavier; Wegner, K David; Resch-Genger, Ute; Rousselin, Yoann; Coll, Jean-Luc; Denat, Franck; Bodio, Ewen; Goze, Christine; Sancey, Lucie.
Affiliation
  • Godard A; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 21078 Dijon, France.
  • Kalot G; Institute for Advanced Biosciences, UGA INSERM U1209 CNRS UMR5309, 38000 Grenoble, France.
  • Pliquett J; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 21078 Dijon, France.
  • Busser B; Institute for Advanced Biosciences, UGA INSERM U1209 CNRS UMR5309, 38000 Grenoble, France.
  • Le Guével X; Grenoble Alpes University Hospital, 38043 Grenoble, France.
  • Wegner KD; Institute for Advanced Biosciences, UGA INSERM U1209 CNRS UMR5309, 38000 Grenoble, France.
  • Resch-Genger U; BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Str. 11, 12489 Berlin, Germany.
  • Rousselin Y; BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Str. 11, 12489 Berlin, Germany.
  • Coll JL; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 21078 Dijon, France.
  • Denat F; Institute for Advanced Biosciences, UGA INSERM U1209 CNRS UMR5309, 38000 Grenoble, France.
  • Bodio E; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 21078 Dijon, France.
  • Goze C; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 21078 Dijon, France.
  • Sancey L; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 21078 Dijon, France.
Bioconjug Chem ; 31(4): 1088-1092, 2020 04 15.
Article in En | MEDLINE | ID: mdl-32227983
A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo. In vitro, the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Boron Compounds / Water / Coloring Agents / Optical Imaging / Infrared Rays Limits: Humans Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2020 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Boron Compounds / Water / Coloring Agents / Optical Imaging / Infrared Rays Limits: Humans Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2020 Type: Article Affiliation country: France