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Diagnostic yield of multigene panel testing in an Israeli cohort: enrichment of low-penetrance variants.
Bernstein-Molho, Rinat; Friedman, Eitan; Kedar, Inbal; Laitman, Yael; Allweis, Tanir M; Gal-Yam, Einav Nili; Feldman, Hagit Baris; Grinshpun, Albert; Halpern, Naama; Hartmajer, Shulamit; Kadouri, Luna; Katz, Lior H; Kaufman, Bella; Laish, Ido; Levanon, Keren; Philipsborn, Shira Litz; Ludman, Mark; Moran, Gal; Peretz, Tamar; Reinstein, Eyal; Levi, Gili Reznick; Safra, Tamar; Shkedi, Shiri; Vinkler, Chana; Levy, Zohar; Goldberg, Yael.
Affiliation
  • Bernstein-Molho R; Breast Cancer Center, Oncology Institute, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.
  • Friedman E; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Kedar I; Susanne Levy Gertner Oncogenetics Unit, The Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.
  • Laitman Y; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Allweis TM; Rabin Medical Center, Recanati Genetics Institute, Beilinson Hospital, Petach Tikva, Israel.
  • Gal-Yam EN; Susanne Levy Gertner Oncogenetics Unit, The Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.
  • Feldman HB; Breast Health Center & Dept of Surgery, Kaplan Medical Center, Rehovot, Israel.
  • Grinshpun A; Hebrew University Medical School, Jerusalem, Israel.
  • Halpern N; The Talpiot Medical Leadership Program, Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel.
  • Hartmajer S; The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Kadouri L; Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
  • Katz LH; Breast Cancer Center, Oncology Institute, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.
  • Kaufman B; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Laish I; Medical Genetics Institute, Meir Medical Center, Kfar-Saba, Israel.
  • Levanon K; Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
  • Philipsborn SL; Department of Gastroenterology and Hepatology, Hadassah Medical Center, Jerusalem, Israel.
  • Ludman M; Breast Cancer Center, Oncology Institute, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.
  • Moran G; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Peretz T; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Reinstein E; Gastroenterology Institute, Chaim Sheba Medical Center, Tel Hasomer, Israel.
  • Levi GR; Breast Cancer Center, Oncology Institute, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.
  • Safra T; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Shkedi S; Medical Genetics Institute, Meir Medical Center, Kfar-Saba, Israel.
  • Vinkler C; Medical Genetics Institute, Meir Medical Center, Kfar-Saba, Israel.
  • Levy Z; Maccabi Health Services, Rehovot, Israel.
  • Goldberg Y; Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Breast Cancer Res Treat ; 181(2): 445-453, 2020 Jun.
Article in En | MEDLINE | ID: mdl-32303989
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Ethnicity / Biomarkers, Tumor / Genetic Testing / Genetic Predisposition to Disease / Early Detection of Cancer / Mutation Type of study: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Middle aged Country/Region as subject: Asia Language: En Journal: Breast Cancer Res Treat Year: 2020 Type: Article Affiliation country: Israel
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Ethnicity / Biomarkers, Tumor / Genetic Testing / Genetic Predisposition to Disease / Early Detection of Cancer / Mutation Type of study: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Middle aged Country/Region as subject: Asia Language: En Journal: Breast Cancer Res Treat Year: 2020 Type: Article Affiliation country: Israel