Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes.
Commun Biol
; 3(1): 180, 2020 04 20.
Article
in En
| MEDLINE
| ID: mdl-32313182
ABSTRACT
Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language. In this paper, we consider the relationship between genetic variants, hearing, auditory processing and language development. We employ whole genome sequencing in a discovery family to target association and gene x environment interaction analyses in two large population cohorts; the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK10K. These investigations indicate that USH2A variants are associated with altered low-frequency sound perception which, in turn, increases the risk of developmental language disorder. We further show that Ush2a heterozygote mice have low-level hearing impairments, persistent higher-order acoustic processing deficits and altered vocalizations. These findings provide new insights into the complexity of genetic mechanisms serving language development and disorders and the relationships between developmental auditory and neural systems.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Auditory Perception
/
Auditory Perceptual Disorders
/
Child Language
/
Extracellular Matrix Proteins
/
Polymorphism, Single Nucleotide
/
Hearing
/
Hearing Disorders
/
Language Development Disorders
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Commun Biol
Year:
2020
Type:
Article
Affiliation country:
United States