The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors.
Int J Mol Sci
; 21(8)2020 Apr 20.
Article
in En
| MEDLINE
| ID: mdl-32325928
ABSTRACT
Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has been a subject of debate, given that this protein may act as either an oncogenic protein or a tumor suppressor in different cell types and contexts. Lately, there is growing evidence that aryl hydrocarbon receptor (AhR) plays an important part in the development of brain tumors. The role of AhR in brain tumors is complicated, depending on the type of tumor, on ligands that activate AhR, and other features of the pathological process. In this review, we summarize current knowledge about AhR in relation to brain tumors and provide an overview of AhR's potential as a therapeutic target.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Receptors, Aryl Hydrocarbon
/
Disease Susceptibility
/
Basic Helix-Loop-Helix Transcription Factors
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2020
Type:
Article
Affiliation country:
RUSSIA