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Benzofuran pyran compound rescues rat and human osteoblast from lipotoxic effect of palmitate by inhibiting lipid biosynthesis and promoting stabilization of RUNX2.
Tripathi, Ashish Kumar; Rai, Divya; Kothari, Priyanka; Kushwaha, Pragati; Sinha, Shradha; Sardar, Anirban; Sashidhara, Koneni V; Trivedi, Ritu.
Affiliation
  • Tripathi AK; Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Rai D; Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Kothari P; Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Kushwaha P; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Sinha S; Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Sardar A; Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Sashidhara KV; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Trivedi R; Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India. Electronic address: ritu_trivedi@cdri.res.in.
Toxicol In Vitro ; 66: 104872, 2020 Aug.
Article in En | MEDLINE | ID: mdl-32330564
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Palmitates / Pyrans / Benzofurans / Core Binding Factor Alpha 1 Subunit / Lipogenesis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2020 Type: Article Affiliation country: India
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Palmitates / Pyrans / Benzofurans / Core Binding Factor Alpha 1 Subunit / Lipogenesis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2020 Type: Article Affiliation country: India