Your browser doesn't support javascript.
loading
Neutrophils play an ongoing role in preventing bacterial pneumonia by blocking the dissemination of Staphylococcus aureus from the upper to the lower airways.
Ge, Chenghao; Monk, Ian R; Monard, Sarah C; Bedford, James G; Braverman, Jessica; Stinear, Timothy P; Wakim, Linda M.
Affiliation
  • Ge C; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
  • Monk IR; School of Medicine, Tsinghua University, Beijing, China.
  • Monard SC; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
  • Bedford JG; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
  • Braverman J; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
  • Stinear TP; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
  • Wakim LM; Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
Immunol Cell Biol ; 98(7): 577-594, 2020 08.
Article in En | MEDLINE | ID: mdl-32333812
ABSTRACT
Staphylococcus aureus is found in the nasal cavity of up to 30% of the human population. Persistent nasal carriage of S. aureus is a risk factor for influenza virus-induced secondary bacterial pneumonia. There is limited understanding of the factors that cause S. aureus to shift from the upper to the lower respiratory tract and convert from a commensal organism to an invasive pathogen. Here we show that neutrophils actively prevent S. aureus dissemination. Establishment of a mouse model of localized S. aureus nasal carriage revealed variations in the longevity of persistence of S. aureus isolates. Improved persistence within this site was associated with reduced nasal inflammation, less neutrophil egress into the airways and reduced neutrophil-bacteria association. Neutrophil depletion of mice with localized S. aureus nasal carriage triggered the development of an invasive S. aureus infection. Moreover, utilizing a model of influenza-induced staphylococcal pneumonia we showed that treatment with granulocyte-colony-stimulating factor, a potent enhancer of neutrophil number and function, significantly reduced bacterial loads in the lung and improved disease outcomes. These data reveal that neutrophils play an important and active role in confining S. aureus to the upper respiratory tract and highlight the use of approaches that improve neutrophil function as effective strategies to attenuate morbidity associated with staphylococcal pneumonia.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Staphylococcal / Lung / Neutrophils Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Immunol Cell Biol Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Staphylococcal / Lung / Neutrophils Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Immunol Cell Biol Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: Australia