Enhanced nanoparticle accumulation by tumor-acidity-activatable release of sildenafil to induce vasodilation.

Zhang, Peng; Zhang, Yu; Ding, Xiaoya; Xiao, Chunsheng; Chen, Xuesi

Zhang, Peng; Zhang, Yu; Ding, Xiaoya; Xiao, Chunsheng; Chen, Xuesi.

Affiliation

Zhang P; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. xiaocs@ciac.ac.cn.

Biomater Sci ; 8(11): 3052-3062, 2020 Jun 07.

Article in En | MEDLINE | ID: mdl-32347852

Subject(s)

Antineoplastic Agents/administration & dosage; Cisplatin/administration & dosage; Melanoma, Experimental/metabolism; Nanoparticles/administration & dosage; Sildenafil Citrate/administration & dosage; Vasodilator Agents/administration & dosage; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacokinetics; Biological Transport; Blood Vessels/physiology; Cell Line, Tumor; Cisplatin/chemistry; Cisplatin/pharmacokinetics; Drug Liberation; Female; Hydrogen-Ion Concentration; Melanoma, Experimental/blood supply; Melanoma, Experimental/chemistry; Melanoma, Experimental/drug therapy; Mice, Inbred C57BL; Micelles; Nanoparticles/chemistry; Polyethylene Glycols/administration & dosage; Polyethylene Glycols/chemistry; Polyethylene Glycols/pharmacokinetics; Polyglutamic Acid/administration & dosage; Polyglutamic Acid/analogs & derivatives; Polyglutamic Acid/chemistry; Polyglutamic Acid/pharmacokinetics; Rats, Sprague-Dawley; Sildenafil Citrate/chemistry; Sildenafil Citrate/pharmacokinetics; Tissue Distribution; Vasodilation; Vasodilator Agents/chemistry; Vasodilator Agents/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilator Agents / Melanoma, Experimental / Cisplatin / Nanoparticles / Sildenafil Citrate / Antineoplastic Agents Language: En Journal: Biomater Sci Year: 2020 Type: Article

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