Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction.
J Int Med Res
; 48(5): 300060519895352, 2020 May.
Article
in En
| MEDLINE
| ID: mdl-32357116
ABSTRACT
OBJECTIVE:
Cerebral infarction has a poor prognosis and causes a serious burden on families and society. Recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are commonly used thrombolytic agents in the clinic. However, direct and powerful clinical trial evidence to determine the therapeutic effect of rt-PA and UK on intravenous thrombolysis is lacking.METHODS:
In this study, 180 patients with acute cerebral infarction were treated with rt-PA or UK. The National Institutes of Health Stroke Scale (NIHSS) scores, Barthel index, bleeding complications, and biomarkers were evaluated.RESULTS:
No significant differences in NIHSS or Barthel scores were found between the groups. However, UK increased the risk of intracranial haemorrhage compared with rt-PA. rt-PA had increased activity in reducing serum levels of MMP-9 than UK.CONCLUSION:
Intravenous thrombolysis with rt-PA and UK in the time window of acute cerebral infarction can achieve similar therapeutic effects, but rt-PA can further reduce the risk of cerebral haemorrhage and is relatively safer than UK.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urokinase-Type Plasminogen Activator
/
Thrombolytic Therapy
/
Cerebral Infarction
/
Tissue Plasminogen Activator
/
Intracranial Hemorrhages
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
J Int Med Res
Year:
2020
Type:
Article
Affiliation country:
China