Regulation of RNA granules by FMRP and implications for neurological diseases.
Traffic
; 21(7): 454-462, 2020 07.
Article
in En
| MEDLINE
| ID: mdl-32374065
ABSTRACT
RNA granule formation, which can be regulated by RNA-binding proteins (RBPs) such as fragile X mental retardation protein (FMRP), acts as a mechanism to control both the repression and subcellular localization of translation. Dysregulated assembly of RNA granules has been implicated in multiple neurological disorders, such as amyotrophic lateral sclerosis. Thus, it is crucial to understand the cellular pathways impinging upon granule assembly or disassembly. The goal of this review is to summarize recent advances in our understanding of the role of the RBP, FMRP, in translational repression underlying RNA granule dynamics, mRNA transport and localized. We summarize the known mechanisms of translational regulation by FMRP, the role of FMRP in RNA transport granules, fragile X granules and stress granules. Focusing on the emerging link between FMRP and stress granules, we propose a model for how hyperassembly and hypoassembly of RNA granules may contribute to neurological diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fragile X Mental Retardation Protein
/
Amyotrophic Lateral Sclerosis
Limits:
Humans
Language:
En
Journal:
Traffic
Journal subject:
FISIOLOGIA
Year:
2020
Type:
Article
Affiliation country:
United States