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Structure of a gut microbial diltiazem-metabolizing enzyme suggests possible substrate binding mode.
Zhou, Shuyu; Ko, Tzu-Ping; Huang, Jian-Wen; Liu, Weidong; Zheng, Yingying; Wu, Shan; Wang, Qian; Xie, Zhenzhen; Liu, Ziwei; Chen, Chun-Chi; Guo, Rey-Ting.
Affiliation
  • Zhou S; School of Life Science, University of Science and Technology of China, Anhui, 230026, China; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
  • Ko TP; Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan. Electronic address: kotping@gate.sinica.edu.tw.
  • Huang JW; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, China.
  • Liu W; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
  • Zheng Y; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
  • Wu S; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, China.
  • Wang Q; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, China.
  • Xie Z; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, China.
  • Liu Z; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, China.
  • Chen CC; State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, China. Electronic address: ccckate0722@hubu.edu.cn
  • Guo RT; School of Life Science, University of Science and Technology of China, Anhui, 230026, China; Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; State Key Laboratory of Biocatalysis and Enzyme Enginee
Biochem Biophys Res Commun ; 527(3): 799-804, 2020 06 30.
Article in En | MEDLINE | ID: mdl-32423809
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Vasodilator Agents / Diltiazem / Gastrointestinal Microbiome / Bacteroides thetaiotaomicron / Hydrolases Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Vasodilator Agents / Diltiazem / Gastrointestinal Microbiome / Bacteroides thetaiotaomicron / Hydrolases Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Type: Article Affiliation country: China