DNA Methylation of CD70 Promoter in Juvenile Systemic Lupus Erythematosus.
Fetal Pediatr Pathol
; 41(1): 58-67, 2022 Feb.
Article
in En
| MEDLINE
| ID: mdl-32427516
ABSTRACT
INTRODUCTION:
Epigenetic alterations in pathogenesis of systemic lupus erythematosus (SLE) have gained more attention recently in adults. We assessed the methylation of CD70 promoter, a costimulatory molecule on T cells, in juvenile SLE (JSLE), and compared this to that found in controls and the literature of adult SLE patients.METHODS:
DNA methylation status was evaluated on peripheral blood from JSLE patients and healthy controls.RESULTS:
Twenty-five patients with JSLE and 24 healthy controls were compared. JSLE patients had lower unmethylated CpG islands compared to the control group (mean ± SD; 0.78 ± 0.42 vs 10503.80 ± 39796.95). However, the difference was not significant (P-value; 0.22).CONCLUSION:
Despite hypomethylation of CD70 gene promoter in CD4+ T-cells from adult patients with SLE, no statistically significant differences observed in patients with JSLE compared with healthy controls. This may suggest a mechanism different in JSLE patients than in adults.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Methylation
/
Lupus Erythematosus, Systemic
Limits:
Child
/
Humans
Language:
En
Journal:
Fetal Pediatr Pathol
Journal subject:
PATOLOGIA
/
PEDIATRIA
Year:
2022
Type:
Article
Affiliation country:
Iran