Immunogenetics in systemic lupus erythematosus: Transitioning from genetic associations to cellular effects.
Scand J Immunol
; 92(4): e12894, 2020 Oct.
Article
in En
| MEDLINE
| ID: mdl-32428248
ABSTRACT
Systemic lupus erythematosus (SLE) is a heterogeneous rheumatic autoimmune disease. Genetic studies have identified up to 100 SLE risk loci. Many of these encode proteins of importance in the immune system, but the cellular and molecular mechanisms underlying these associations are still elusive. In this review, we will highlight some of the SLE risk loci where mechanistic insights have been achieved recently by linking genetic risk polymorphisms to cellular or molecular phenotypes important for the disease process.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunogenetic Phenomena
/
Lupus Erythematosus, Systemic
Limits:
Humans
Language:
En
Journal:
Scand J Immunol
Year:
2020
Type:
Article
Affiliation country:
Sweden