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Pathogenesis of Influenza A(H7N9) Virus in Aged Nonhuman Primates.
Fukuyama, Satoshi; Iwatsuki-Horimoto, Kiyoko; Kiso, Maki; Nakajima, Noriko; Gregg, Robert W; Katsura, Hiroaki; Tomita, Yuriko; Maemura, Tadashi; da Silva Lopes, Tiago Jose; Watanabe, Tokiko; Shoemaker, Jason E; Hasegawa, Hideki; Yamayoshi, Seiya; Kawaoka, Yoshihiro.
Affiliation
  • Fukuyama S; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Iwatsuki-Horimoto K; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Kiso M; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Nakajima N; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Gregg RW; Department of Chemical and Petroleum Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Katsura H; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Tomita Y; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Maemura T; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • da Silva Lopes TJ; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Watanabe T; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Shoemaker JE; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Hasegawa H; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Yamayoshi S; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Kawaoka Y; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
J Infect Dis ; 222(7): 1155-1164, 2020 09 01.
Article in En | MEDLINE | ID: mdl-32433769
ABSTRACT
The avian influenza A(H7N9) virus has caused high mortality rates in humans, especially in the elderly; however, little is known about the mechanistic basis for this. In the current study, we used nonhuman primates to evaluate the effect of aging on the pathogenicity of A(H7N9) virus. We observed that A(H7N9) virus infection of aged animals (defined as age 20-26 years) caused more severe symptoms than infection of young animals (defined as age 2-3 years). In aged animals, lung inflammation was weak and virus infection was sustained. Although cytokine and chemokine expression in the lungs of most aged animals was lower than that in the lungs of young animals, 1 aged animal showed severe symptoms and dysregulated proinflammatory cytokine and chemokine production. These results suggest that attenuated or dysregulated immune responses in aged animals are responsible for the severe symptoms observed among elderly patients infected with A(H7N9) virus.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Orthomyxoviridae Infections / Influenza A Virus, H7N9 Subtype / Lung Limits: Animals Language: En Journal: J Infect Dis Year: 2020 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Orthomyxoviridae Infections / Influenza A Virus, H7N9 Subtype / Lung Limits: Animals Language: En Journal: J Infect Dis Year: 2020 Type: Article Affiliation country: Japan