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Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Lu, Wei-Cheng; Saha, Achinto; Yan, Wupeng; Garrison, Kendra; Lamb, Candice; Pandey, Renu; Irani, Seema; Lodi, Alessia; Lu, Xiyuan; Tiziani, Stefano; Zhang, Yan Jessie; Georgiou, George; DiGiovanni, John; Stone, Everett.
Affiliation
  • Lu WC; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
  • Saha A; Division of Pharmacology and Toxicology, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78712.
  • Yan W; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.
  • Garrison K; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
  • Lamb C; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
  • Pandey R; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712.
  • Irani S; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
  • Lodi A; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712.
  • Lu X; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712.
  • Tiziani S; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712.
  • Zhang YJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.
  • Georgiou G; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712.
  • DiGiovanni J; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712; gg@che.utexas.edu john.digiovanni@austin.utexas.edu stonesci@utexas.edu.
  • Stone E; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.
Proc Natl Acad Sci U S A ; 117(23): 13000-13011, 2020 06 09.
Article in En | MEDLINE | ID: mdl-32434918
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Mutagenesis, Site-Directed / Cystathionine gamma-Lyase / Methionine Limits: Animals / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Mutagenesis, Site-Directed / Cystathionine gamma-Lyase / Methionine Limits: Animals / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article