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Discovery of small-molecule enzyme activators by activity-based protein profiling.
Kok, Bernard P; Ghimire, Srijana; Kim, Woojoo; Chatterjee, Shreyosree; Johns, Tyler; Kitamura, Seiya; Eberhardt, Jerome; Ogasawara, Daisuke; Xu, Janice; Sukiasyan, Ara; Kim, Sean M; Godio, Cristina; Bittencourt, Julia M; Cameron, Michael; Galmozzi, Andrea; Forli, Stefano; Wolan, Dennis W; Cravatt, Benjamin F; Boger, Dale L; Saez, Enrique.
Affiliation
  • Kok BP; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Ghimire S; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
  • Kim W; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Chatterjee S; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
  • Johns T; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Kitamura S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Eberhardt J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Ogasawara D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
  • Xu J; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Sukiasyan A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Kim SM; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Godio C; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Bittencourt JM; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Cameron M; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
  • Galmozzi A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Wolan DW; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
  • Boger DL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. boger@scripps.edu.
  • Saez E; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA. esaez@scripps.edu.
Nat Chem Biol ; 16(9): 997-1005, 2020 09.
Article in En | MEDLINE | ID: mdl-32514184
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Activators / Small Molecule Libraries / Lysophospholipase Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2020 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Activators / Small Molecule Libraries / Lysophospholipase Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2020 Type: Article Affiliation country: United States