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Cytotoxic triterpenoids from the stem bark of Aglaia angustifolia.
Hutagaol, Ricson Pemimpin; Harneti, Desi; Safari, Agus; Hidayat, Ace Tatang; Supratman, Unang; Awang, Khalijah; Shiono, Yoshihito.
Affiliation
  • Hutagaol RP; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Indonesia.
  • Harneti D; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Nusa Bangsa, Jl Sholeh Iskandar Km 4, Bogor 16166, Indonesia.
  • Safari A; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Indonesia.
  • Hidayat AT; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Indonesia.
  • Supratman U; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Indonesia.
  • Awang K; Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Shiono Y; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Indonesia.
J Asian Nat Prod Res ; 23(8): 781-788, 2021 Aug.
Article in En | MEDLINE | ID: mdl-32536210
ABSTRACT
A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3ß,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark of Aglaia angustifolia Miq. The Chemical structure of the new compounds was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells. Among those compounds, angustifolianin (1) showed strongest cytotoxic activity with an IC50 value of 50.5 µg/ml.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Aglaia / Antineoplastic Agents Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Type: Article Affiliation country: Indonesia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Aglaia / Antineoplastic Agents Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Type: Article Affiliation country: Indonesia