Gene Panel Sequencing Identifies Novel Pathogenic Mutations in Moroccan Patients with Familial Parkinson Disease.

Smaili, Imane; Tesson, Christelle; Regragui, Wafa; Bertrand, Hélène; Rahmani, Mounia; Bouslam, Naima; Benomar, Ali; Brice, Alexis; Lesage, Suzanne; Bouhouche, Ahmed

Smaili, Imane; Tesson, Christelle; Regragui, Wafa; Bertrand, Hélène; Rahmani, Mounia; Bouslam, Naima; Benomar, Ali; Brice, Alexis; Lesage, Suzanne; Bouhouche, Ahmed.

Affiliation

Smaili I; Neurology and Neurogenetics, Faculty of Medicine and Pharmacy, Genomics Center of Human Pathologies, University Mohammed V, Rabat, Morocco.
Tesson C; UPMC Université Paris 6 UMR_S 1127, INSERM U 1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Universités, Paris, France.
Regragui W; Neurology and Neurogenetics, Faculty of Medicine and Pharmacy, Genomics Center of Human Pathologies, University Mohammed V, Rabat, Morocco.
Bertrand H; Department of Neurology and Neurogenetics, Specialties hospital, Rabat, Morocco.
Rahmani M; UPMC Université Paris 6 UMR_S 1127, INSERM U 1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Universités, Paris, France.
Bouslam N; Neurology and Neurogenetics, Faculty of Medicine and Pharmacy, Genomics Center of Human Pathologies, University Mohammed V, Rabat, Morocco.
Benomar A; Department of Neurology and Neurogenetics, Specialties hospital, Rabat, Morocco.
Brice A; Department of Neurology and Neurogenetics, Specialties hospital, Rabat, Morocco.
Lesage S; Neurology and Neurogenetics, Faculty of Medicine and Pharmacy, Genomics Center of Human Pathologies, University Mohammed V, Rabat, Morocco.
Bouhouche A; Department of Neurology and Neurogenetics, Specialties hospital, Rabat, Morocco.

J Mol Neurosci ; 71(1): 142-152, 2021 Jan.

Article in En | MEDLINE | ID: mdl-32557143

Subject(s)

Mutation; Parkinson Disease/genetics; Adult; Age of Onset; Aged; Alleles; Consanguinity; Female; Genes, Dominant; Genes, Recessive; Genetic Association Studies; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Morocco/epidemiology; Multiplex Polymerase Chain Reaction; Nerve Tissue Proteins/genetics; Parkinson Disease/epidemiology; Polymorphism, Single Nucleotide; Sequence Alignment; Sequence Homology, Nucleic Acid; Symptom Assessment

Key words

Familial forms; Gene panel next-generation sequencing; Parkinson disease; Pathogenic mutations

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Mutation Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Africa Language: En Journal: J Mol Neurosci Journal subject: BIOLOGIA MOLECULAR / NEUROLOGIA Year: 2021 Type: Article Affiliation country: Morocco

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