Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells.
Trends Biochem Sci
; 45(10): 858-873, 2020 10.
Article
in En
| MEDLINE
| ID: mdl-32595066
ABSTRACT
The numerous biological roles of NAD+ are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD+ on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD+ levels in cells, as well as how the modulation of NAD+ synthesis dynamically regulates signaling by controlling subcellular NAD+ concentrations. We further discuss potential benefits to the cell of compartmentalizing NAD+, and methods for measuring subcellular NAD+ levels.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Subcellular Fractions
/
Cell Compartmentation
/
NAD
Limits:
Animals
Language:
En
Journal:
Trends Biochem Sci
Year:
2020
Type:
Article