Remodeling Matrix Synthesis in a Rat Model of Aortocaval Fistula and the Cyclic Stretch: Impaction in Pulmonary Arterial Hypertension-Congenital Heart Disease.

Chang, Chi-Jen; Huang, Chung-Chi; Chen, Po-Ru; Lai, Ying-Ju

Chang, Chi-Jen; Huang, Chung-Chi; Chen, Po-Ru; Lai, Ying-Ju.

Affiliation

Chang CJ; Cardiovascular Division, Chang Gung Memorial Hospital Chang Gung University, Linkou, Tao-Yuan 33353, Taiwan.
Huang CC; Department of Respiratory Therapy, Chang Gung University College of Medicine, Tao-Yuan 33353, Taiwan.
Chen PR; Division of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Tao-Yuan 33353, Taiwan.
Lai YJ; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Tao-Yuan 33353, Taiwan.

Int J Mol Sci ; 21(13)2020 Jun 30.

Article in En | MEDLINE | ID: mdl-32630068

Subject(s)

Collagen/metabolism; Elastin/metabolism; Pulmonary Arterial Hypertension/metabolism; Pulmonary Artery/metabolism; Vascular Remodeling; Animals; Disease Models, Animal; Humans; Hypertrophy, Right Ventricular/etiology; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Pulmonary Arterial Hypertension/complications; Pulmonary Arterial Hypertension/physiopathology; Pulmonary Artery/physiopathology; Pulmonary Circulation; Rats; Receptors, Notch/metabolism; Stress, Mechanical; Vascular Stiffness

Key words

cell stretch-induced response; smooth muscle cell; volume-overloading induced pulmonary hypertension

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Artery / Collagen / Elastin / Vascular Remodeling / Pulmonary Arterial Hypertension Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Taiwan

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