The Role of the Human Cytomegalovirus UL133-UL138 Gene Locus in Latency and Reactivation.
Viruses
; 12(7)2020 07 01.
Article
in En
| MEDLINE
| ID: mdl-32630219
ABSTRACT
Human cytomegalovirus (HCMV) latency, the means by which the virus persists indefinitely in an infected individual, is a major frontier of current research efforts in the field. Towards developing a comprehensive understanding of HCMV latency and its reactivation from latency, viral determinants of latency and reactivation and their host interactions that govern the latent state and reactivation from latency have been identified. The polycistronic UL133-UL138 locus encodes determinants of both latency and reactivation. In this review, we survey the model systems used to investigate latency and new findings from these systems. Particular focus is given to the roles of the UL133, UL135, UL136 and UL138 proteins in regulating viral latency and how their known host interactions contribute to regulating host signaling pathways towards the establishment of or exit from latency. Understanding the mechanisms underlying viral latency and reactivation is important in developing strategies to block reactivation and prevent CMV disease in immunocompromised individuals, such as transplant patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viral Proteins
/
Virus Activation
/
Virus Latency
/
Cytomegalovirus Infections
/
Cytomegalovirus
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Viruses
Year:
2020
Type:
Article
Affiliation country:
United States