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Optimization of AsCas12a for combinatorial genetic screens in human cells.
DeWeirdt, Peter C; Sanson, Kendall R; Sangree, Annabel K; Hegde, Mudra; Hanna, Ruth E; Feeley, Marissa N; Griffith, Audrey L; Teng, Teng; Borys, Samantha M; Strand, Christine; Joung, J Keith; Kleinstiver, Benjamin P; Pan, Xuewen; Huang, Alan; Doench, John G.
Affiliation
  • DeWeirdt PC; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Sanson KR; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Sangree AK; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Hegde M; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Hanna RE; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Feeley MN; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Griffith AL; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Teng T; Tango Therapeutics, Cambridge, MA, USA.
  • Borys SM; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Strand C; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Joung JK; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Kleinstiver BP; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.
  • Pan X; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.
  • Huang A; Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • Doench JG; Department of Pathology, Harvard Medical School, Boston, MA, USA.
Nat Biotechnol ; 39(1): 94-104, 2021 01.
Article in En | MEDLINE | ID: mdl-32661438
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / RNA, Guide, Kinetoplastida / Endodeoxyribonucleases / CRISPR-Associated Proteins / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Biotechnol Journal subject: BIOTECNOLOGIA Year: 2021 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / RNA, Guide, Kinetoplastida / Endodeoxyribonucleases / CRISPR-Associated Proteins / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Biotechnol Journal subject: BIOTECNOLOGIA Year: 2021 Type: Article Affiliation country: United States