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Mitoxantrone, pixantrone and mitoxantrone (2-hydroxyethyl)piperazine are toll-like receptor 4 antagonists, inhibit NF-κB activation, and decrease TNF-alpha secretion in primary microglia.
Rinne, Maiju; Mätlik, Kert; Ahonen, Tiina; Vedovi, Fabio; Zappia, Giovanni; Moreira, Vânia M; Yli-Kauhaluoma, Jari; Leino, Sakari; Salminen, Outi; Kalso, Eija; Airavaara, Mikko; Xhaard, Henri.
Affiliation
  • Rinne M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
  • Mätlik K; Institute of Biotechnology, HiLIFE, University of Helsinki, FI-00014 Helsinki, Finland; Department of Pharmacology, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland.
  • Ahonen T; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
  • Vedovi F; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland; Department of Biomolecular Sciences, University Urbino Carlo Bo, P.zza Rinascimento, 6 61029 Urbino (PU), Italy.
  • Zappia G; Department of Biomolecular Sciences, University Urbino Carlo Bo, P.zza Rinascimento, 6 61029 Urbino (PU), Italy.
  • Moreira VM; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, G4 0RE Glasgow, U.K; Laboratory of Pharmaceutical Chemistry, Facu
  • Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
  • Leino S; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
  • Salminen O; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
  • Kalso E; Department of Pharmacology, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland; Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital. FI-00029 HUS, Finland.
  • Airavaara M; Institute of Biotechnology, HiLIFE, University of Helsinki, FI-00014 Helsinki, Finland.
  • Xhaard H; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address: henri.xhaard@helsinki.fi.
Eur J Pharm Sci ; 154: 105493, 2020 Nov 01.
Article in En | MEDLINE | ID: mdl-32730846
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Toll-Like Receptor 4 / Piperazine / Isoquinolines Type of study: Prognostic_studies Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2020 Type: Article Affiliation country: Finland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Toll-Like Receptor 4 / Piperazine / Isoquinolines Type of study: Prognostic_studies Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2020 Type: Article Affiliation country: Finland