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Circulating serum exosomal miR-20b-5p and miR-3187-5p as efficient diagnostic biomarkers for early-stage non-small cell lung cancer.
Zhang, Zhi-Jun; Song, Xing-Guo; Xie, Li; Wang, Kang-Yu; Tang, You-Yong; Yu, Miao-; Feng, Xiao-Dong; Song, Xian-Rang.
Affiliation
  • Zhang ZJ; Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Cheeloo College of Medicine, Shandong University, Shandong 250117, China.
  • Song XG; Department of Clinical Laboratory, Taian City Central Hospital, Shandong 271000, China.
  • Xie L; Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong 250117, China.
  • Wang KY; Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong 250117, China.
  • Tang YY; Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong 250117, China.
  • Yu M; Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong 250117, China.
  • Feng XD; Department of Clinical Laboratory, Shandong Provincial Third Hospital, Cheeloo college of Medicine, Shandong University, Shandong 250031, China.
  • Song XR; Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Shandong 266000, China.
Exp Biol Med (Maywood) ; 245(16): 1428-1436, 2020 10.
Article in En | MEDLINE | ID: mdl-32741216
IMPACT STATEMENT: The high mortality of non-small cell lung cancer (NSCLC) is mainly because the cancer has progressed to a more advanced stage before diagnosis. If NSCLC can be diagnosed at early stages, especially stage 0 or I, the overall survival rate will be largely improved by definitive treatment such as lobectomy. We herein validated two novel circulating serum ExmiRs as diagnostic biomarkers for early-stage NSCLC to fulfill the unmet medical need. Considering the number of specimens in this study, circulating serum exosomal miR-20b-5p and miR-3187-5p are putative NSCLC biomarkers, which need to be further investigated in a larger randomized controlled clinical trial.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Carcinoma, Non-Small-Cell Lung / MicroRNAs / Exosomes / Circulating MicroRNA / Lung Neoplasms Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Exp Biol Med (Maywood) Journal subject: BIOLOGIA / FISIOLOGIA / MEDICINA Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Carcinoma, Non-Small-Cell Lung / MicroRNAs / Exosomes / Circulating MicroRNA / Lung Neoplasms Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Exp Biol Med (Maywood) Journal subject: BIOLOGIA / FISIOLOGIA / MEDICINA Year: 2020 Type: Article Affiliation country: China