Acetaldehyde suppresses HBV-MHC class I complex presentation on hepatocytes via induction of ER stress and Golgi fragmentation.

Ganesan, Murali; Mathews, Saumi; Makarov, Edward; Petrosyan, Armen; Kharbanda, Kusum K; Kidambi, Srivatsan; Poluektova, Larisa Y; Casey, Carol A; Osna, Natalia A

Ganesan, Murali; Mathews, Saumi; Makarov, Edward; Petrosyan, Armen; Kharbanda, Kusum K; Kidambi, Srivatsan; Poluektova, Larisa Y; Casey, Carol A; Osna, Natalia A.

Affiliation

Ganesan M; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska.
Mathews S; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
Makarov E; Department of Pharmacology and Experimental Neuroscience, Omaha, Nebraska.
Petrosyan A; Department of Pharmacology and Experimental Neuroscience, Omaha, Nebraska.
Kharbanda KK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.
Kidambi S; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska.
Poluektova LY; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
Casey CA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.
Osna NA; Department of Chemical and Biomolecular Engineering, University of Nebraska at Lincoln, Nebraska.

Am J Physiol Gastrointest Liver Physiol ; 319(4): G432-G442, 2020 10 01.

Article in En | MEDLINE | ID: mdl-32755306

Subject(s)

Antigen Presentation/drug effects; Endoplasmic Reticulum Stress/drug effects; Golgi Apparatus/drug effects; Hepatitis B virus/immunology; Histocompatibility Antigens Class I/immunology; Liver/virology; Acetaldehyde; Endoplasmic Reticulum Stress/genetics; Gene Expression/drug effects; Golgi Apparatus/ultrastructure; HLA-A2 Antigen/analysis; Hep G2 Cells; Hepatitis B virus/genetics; Histocompatibility Antigens Class I/drug effects; Humans; Liver/immunology; RNA, Messenger/analysis; Transfection; Unfolded Protein Response/drug effects; Unfolded Protein Response/genetics

Key words

ER stress; Golgi; HBV; acetaldehyde; hepatocytes

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histocompatibility Antigens Class I / Hepatitis B virus / Antigen Presentation / Endoplasmic Reticulum Stress / Golgi Apparatus / Liver Limits: Humans Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2020 Type: Article

Fulltext

XML

PubMed Links

Search on Google