ß-adrenergic activation may promote myosin light chain kinase degradation through calpain in pressure overload-induced cardiac hypertrophy: ß-adrenergic activation results in MLCK degradation.

Wang, Shun; Wang, Haixiong; Su, Xiaoling; Liu, Beilei; Wang, Le; Yan, Hui; Mao, Shuai; Huang, He; Huang, Congxin; Cheng, Mian; Wu, Gang

Wang, Shun; Wang, Haixiong; Su, Xiaoling; Liu, Beilei; Wang, Le; Yan, Hui; Mao, Shuai; Huang, He; Huang, Congxin; Cheng, Mian; Wu, Gang.

Affiliation

Wang S; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China.
Wang H; Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, 030001, China.
Su X; Department of Cardiology, Qinghai Provincial People's Hospital, Xining, 810007, China.
Liu B; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China.
Wang L; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China.
Yan H; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China.
Mao S; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China.
Huang H; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China.
Huang C; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China.
Cheng M; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address: cheng.mian@icloud.com.
Wu G; Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Wuhan, 430060, China; Department of Cardiology, Ezhou Hospital, Renmin Hospital of Wuhan University, Ezhou, 436000, China. Electronic address: wugangmd@163.com.

Biomed Pharmacother ; 129: 110438, 2020 Sep.

Article in En | MEDLINE | ID: mdl-32768940

Subject(s)

Calpain/metabolism; Hypertrophy, Left Ventricular/enzymology; Myocytes, Cardiac/enzymology; Myosin-Light-Chain Kinase/metabolism; Receptors, Adrenergic, beta/metabolism; Ventricular Function, Left; Ventricular Remodeling; Adrenergic beta-Agonists/pharmacology; Adrenergic beta-Antagonists/pharmacology; Animals; Calpain/antagonists & inhibitors; Cardiac Myosins/metabolism; Cells, Cultured; Cysteine Proteinase Inhibitors/pharmacology; Disease Models, Animal; Enzyme Stability; Hypertrophy, Left Ventricular/drug therapy; Hypertrophy, Left Ventricular/physiopathology; Male; Myocytes, Cardiac/drug effects; Myosin Light Chains/metabolism; Phosphorylation; Proteolysis; Rats, Sprague-Dawley; Receptors, Adrenergic, beta/drug effects; Ventricular Function, Left/drug effects; Ventricular Remodeling/drug effects

Key words

Calpain; Cardiac hypertrophy; Myosin light chain kinase; ß-adrenergic activity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myosin-Light-Chain Kinase / Calpain / Ventricular Function, Left / Receptors, Adrenergic, beta / Hypertrophy, Left Ventricular / Ventricular Remodeling / Myocytes, Cardiac Limits: Animals Language: En Journal: Biomed Pharmacother Year: 2020 Type: Article Affiliation country: China

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