Clinical response to 2 protocols of aerosolized gentamicin in 46 dogs with Bordetella bronchiseptica infection (2012-2018).
J Vet Intern Med
; 34(5): 2078-2085, 2020 Sep.
Article
in En
| MEDLINE
| ID: mdl-32790103
ABSTRACT
BACKGROUND:
Bordetella bronchiseptica (Bb) infection commonly causes respiratory disease in dogs. Gentamicin delivered by aerosol maximizes local drug delivery without systemic absorption but clinical response to protocols remains undetermined.OBJECTIVES:
To compare the clinical response to 2 protocols of aerosolized delivery of gentamicin in bordetellosis. ANIMALS Forty-six dogs with Bb infection confirmed by culture or quantitative polymerase chain reaction on bronchoalveolar lavage.METHODS:
Retrospective study. Administration of aerosolized gentamicin for ≥10 minutes q12h for ≥3 weeks using 4 mg/kg diluted with saline (group 1) or undiluted 5% solution (group 2). Clinical response firstly assessed after 3-4 weeks and treatment pursued by 3-weeks increments if cure not reached. Cure defined as absence of cough persisting at least a week after treatment interruption.RESULTS:
Demographic data were similar between both groups. Clinical cure at 3-4 weeks was more frequently observed with the use of undiluted solution (19/33 vs 3/13 dogs, P = .03) in association with a shorter median duration of treatment (4 vs 6 weeks, P = .01). Dogs from group 2 having less than 1000 cells/µL in lavage were also more likely to be cured at 3-4 weeks than dogs with more than 1000 cells/µL [9/9 vs 10/19, P = .006] and median duration of treatment in that subgroup of animals was reduced (3 vs 5 weeks, P = .02). CONCLUSION AND CLINICAL IMPORTANCE Aerosolized delivery of gentamicin seems effective for inducing clinical cure in Bb infection. Clinical response appears better using undiluted 5% solution, particularly in the subgroup of dogs having less than 1000 cells/µL in lavage.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bordetella Infections
/
Bordetella bronchiseptica
/
Dog Diseases
Type of study:
Guideline
/
Observational_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
J Vet Intern Med
Journal subject:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Year:
2020
Type:
Article
Affiliation country:
Belgium